Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10124296" target="_blank" >RIV/00216208:11310/13:10124296 - isvavai.cz</a>
Result on the web
<a href="http://www.bioone.org/doi/full/10.1645/GE-3237.1" target="_blank" >http://www.bioone.org/doi/full/10.1645/GE-3237.1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1645/GE-3237.1" target="_blank" >10.1645/GE-3237.1</a>
Alternative languages
Result language
angličtina
Original language name
Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei
Original language description
The bloodstream form of T. brucei acquires iron from transferrin via receptor-mediated endocytosis. However, it is unknown how procyclic forms that cannot bind transferrin acquire iron. In this study, we show that the procyclic form of T. brucei efficiently takes up iron from ferric complexes via a reductive mechanism and that iron obtained using this mechanism is transported to and used in the mitochondria. The affinity of the transport system is comparable to that of Saccharomyces cerevisiae, with anapparent Km of 0.85 ?M.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC07032" target="_blank" >LC07032: Center for Functional Genetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Parasitology
ISSN
0022-3395
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
363-364
UT code for WoS article
000322520700031
EID of the result in the Scopus database
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