A NO photoreleasing supramolecular hydrogel with bactericidal action

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10139607" target="_blank" >RIV/00216208:11310/13:10139607 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c3tb20473a" target="_blank" >http://dx.doi.org/10.1039/c3tb20473a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c3tb20473a" target="_blank" >10.1039/c3tb20473a</a>

Result language
angličtina
Original language name
A NO photoreleasing supramolecular hydrogel with bactericidal action
Original language description
We have developed an engineered hydrogel formed, in the absence of any toxic solvents or reagents, by spontaneous self-assembly of three key components: a poly-beta-cyclodextrin polymer (1), a hydrophobically modified dextran (2) and a nitric oxide (NO)photodonor bearing an adamantyl appendage (3). The formation of this supramolecular assembly is based on a "lock-and-key" mechanism in which the alkyl side chains of 2 and the adamantane moiety of 3 form inclusion complexes with the beta-CD cavities of 1. The multivalent character of the interactions between all components and the insolubility of the NO photodonor in an aqueous medium ensure the stability of the hydrogel and the total lack of leaching of the photoactive component from the gel network under physiological conditions, even in the absence of protective coating agents. The photochemical properties of the NO photodonor are well preserved in the supramolecular matrix as demonstrated by the remote-controlled release of NO throu
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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