Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10139879" target="_blank" >RIV/00216208:11310/13:10139879 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/00032719.2013.814058" target="_blank" >http://dx.doi.org/10.1080/00032719.2013.814058</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00032719.2013.814058" target="_blank" >10.1080/00032719.2013.814058</a>
Alternative languages
Result language
angličtina
Original language name
Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers
Original language description
Supercritical fluid chromatography employing chiral stationary phases is a popular separation technique to perform enantioselective separations. The main advantages of supercritical fluid chromatography are low analysis time, low consumption of organic modifiers, and therefore lower costs and higher environmental friendliness. A novel method for the separation of chlorthalidone enantiomers, widely used diuretic drug, is reported that clearly demonstrates the advantages of supercritical fluid chromatography. The effects of the amount and type of organic modifiers, temperature, and back pressure on enantioselectivity and resolution of the enantiomers were evaluated. The baseline separation was achieved in less than 2.5 min in the optimized system composed of Chiralpak AD column, mobile phase CO2/ MeOH 50/50 (v/v), temperature 40C, a flow rate of 4.0mL/min, and 120 bar back pressure. Moreover, enantiomers of chlorthalidone were determined in two commercially available pharmaceuticals. The
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH11018" target="_blank" >LH11018: Cyclofructans and their derivatives as new chiral selectors for liquid chromatography and capillary electrophoresis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analytical Letters
ISSN
0003-2719
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
18
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2860-2869
UT code for WoS article
000327180300006
EID of the result in the Scopus database
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