HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10134203" target="_blank" >RIV/00216208:11310/13:10134203 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s10337-013-2426-6" target="_blank" >http://dx.doi.org/10.1007/s10337-013-2426-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-013-2426-6" target="_blank" >10.1007/s10337-013-2426-6</a>

Result language

angličtina

Original language name

HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol

Original language description

HPLC method enabling chiral separation and determination of citalopram (CIT), a widely used antidepressant, and its synthetic precursor citadiol in one analysis was developed and validated. Moreover, supercritical fluid chromatography was also tested andwas proved to be less effective for this separation purpose. The optimized HPLC system was composed of Chiralcel OD-H column and n-hexane/propane-2-ol/triethylamine 96/4/0.1 (v/v/v) as mobile phase, column temperature 25 C, flow rate 1.0 mL min-1, UV detection at 250 nm. The effects of amount of propane-2-ol, triethylamine addition, and temperature on enantioselectivity and resolution of the enantiomers were evaluated. The method was found to be suitable for determination of the enantiomeric purity ofCIT in bulk drugs. Enantiomers of CIT were determined in two commercially available pharmaceuticals.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/LH11018" target="_blank" >LH11018: Cyclofructans and their derivatives as new chiral selectors for liquid chromatography and capillary electrophoresis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chromatographia

ISSN

0009-5893

e-ISSN

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Volume of the periodical

76

Issue of the periodical within the volume

9-10

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

483-489

UT code for WoS article

000318168100006

EID of the result in the Scopus database

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