The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10145929" target="_blank" >RIV/00216208:11310/13:10145929 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/13:43906767 RIV/00064173:_____/13:#0000332 RIV/00023728:_____/14:#0003047
Result on the web
<a href="http://dx.doi.org/10.1007/s00296-012-2472-7" target="_blank" >http://dx.doi.org/10.1007/s00296-012-2472-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00296-012-2472-7" target="_blank" >10.1007/s00296-012-2472-7</a>

Result language
angličtina
Original language name
The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population
Original language description
Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to both diseases. We tested on an association of HLA-Cw allelesand functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw*06 allele and PsV (P (corrected) = 0.0013) that was most prominent in early onset disease subtype (P (corrected) = 0.0013). The association between HLA-Cw*06 and PsA was low (P (corrected) = 0.0585) and restricted to PsA patients with early PsV onset (P (corrected) = 0.0195). We found no association of -1149 G/T P
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/NS10618" target="_blank" >NS10618: The role of the prolactin gene polymorphism and its expression in peripheral mononuclear cells in the autoimmune diseases pathogenesis ? systemic lupus erythematosus, inflammatory joint diseases (psoriatic and rheumatoid arthritis) and psoriasis vulgaris</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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