Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002496" target="_blank" >RIV/00216208:11120/10:00002496 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/10:#0000025 RIV/00216208:11310/10:10080384
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis
Original language description
Extrapituitary prolactin (PRL) production is regulated by the alternative promoter which contains functional single nucleotide polymorphism -1149 G/T. G allele of this SNP leads to higher mRNA PRL synthesis in lymphocytes. Polymyositis (PM) and systemicsclerosis (SSc) have been associated with increased serum PRL levels, lymphocytes of patients with SSc produce more PRL mRNA. In our association study we tested 75 patients with SSc, 115 patients with polymyositis/dermatomyositis and 123 healthy individuals for -1149 G/T SNP of the extrapituitary PRL promoter. The genotype and allele distribution did not show any differences in groups of PM, DM and SSc patients compared to healthy individuals. However, we found a significant inverse association betweenTT genotype in SSc patients with disease onset above 45 years compared to individuals with SSc and diseases onset prior 45 years and healthy subjects.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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