Vinylsulfonamide and Acrylamide Modification of DNA for Cross-linking with Proteins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10159263" target="_blank" >RIV/00216208:11310/13:10159263 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00398521 RIV/61388963:_____/13:00398521 RIV/00216224:14740/13:00072685
Result on the web
<a href="http://dx.doi.org/10.1002/anie.201303577" target="_blank" >http://dx.doi.org/10.1002/anie.201303577</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201303577" target="_blank" >10.1002/anie.201303577</a>

Result language
angličtina
Original language name
Vinylsulfonamide and Acrylamide Modification of DNA for Cross-linking with Proteins
Original language description
Novel bioorthogonal covalent cross-link of DNA-binding proteins (p53) to DNA was achieved through novel DNA probes bearing a reactive vinylsulfonamide (VS) group. The VS-modified dCTP served as building block for polymerase synthesis of modified DNA which was readily conjugated with cysteine containing peptides and proteins through Michael addition.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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