An Advanced System of the Mitochondrial Processing Peptidase and Core Protein Family in Trypanosoma brucei and Multiple Origins of the Core I Subunit in Eukaryotes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10189475" target="_blank" >RIV/00216208:11310/13:10189475 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/13:00397003 RIV/61388971:_____/13:00397003 RIV/60076658:12310/13:43885261
Result on the web
<a href="http://dx.doi.org/10.1093/gbe/evt056" target="_blank" >http://dx.doi.org/10.1093/gbe/evt056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/gbe/evt056" target="_blank" >10.1093/gbe/evt056</a>

Result language
angličtina
Original language name
An Advanced System of the Mitochondrial Processing Peptidase and Core Protein Family in Trypanosoma brucei and Multiple Origins of the Core I Subunit in Eukaryotes
Original language description
Mitochondrial processing peptidase (MPP) consists of alpha and beta subunits that catalyze the cleavage of N-terminal mitochondrial-targeting sequences (N-MTSs) and deliver preproteins to the mitochondria. In plants, both MPP subunits are associated withthe respiratory complex bc(1), which has been proposed to represent an ancestral form. Subsequent duplication of MPP subunits resulted in separate sets of genes encoding soluble MPP in the matrix and core proteins (cp1 and cp2) of the membrane-embeddedbc(1) complex. As only alpha-MPP was duplicated in Neurospora, its single beta-MPP functions in both MPP and bc(1) complexes. Herein, we investigated the MPP/core protein family and N-MTSs in the kinetoplastid Trypanosoma brucei, which is often considered one of the most ancient eukaryotes. Analysis of N-MTSs predicted in 336 mitochondrial proteins showed that trypanosomal N-MTSs were comparable with N-MTSs from other organisms. N-MTS cleavage is mediated by a standard heterodimeric MPP,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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