Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10190509" target="_blank" >RIV/00216208:11310/13:10190509 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/13:00395042 RIV/60460709:41210/13:60053 RIV/60460709:41340/13:60053
Result on the web
<a href="http://www.academia.edu/3513300/Inhibition_of_in_vitro_leukotriene_B4_biosynthesis_in_human_neutrophil_granulocytes_and_docking_studies_of_natural_quinones" target="_blank" >http://www.academia.edu/3513300/Inhibition_of_in_vitro_leukotriene_B4_biosynthesis_in_human_neutrophil_granulocytes_and_docking_studies_of_natural_quinones</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones
Original language description
Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the h
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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