Redox and Non-Redox Mechanism of In Vitro Cyclooxygenase Inhibition by Natural Quinones

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F12%3A00380682" target="_blank" >RIV/61389030:_____/12:00380682 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/12:54642 RIV/60460709:41340/12:#0000005

Result on the web

<a href="http://dx.doi.org/10.1055/s-0031-1280430" target="_blank" >http://dx.doi.org/10.1055/s-0031-1280430</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0031-1280430" target="_blank" >10.1055/s-0031-1280430</a>

Result language

angličtina

Original language name

Redox and Non-Redox Mechanism of In Vitro Cyclooxygenase Inhibition by Natural Quinones

Original language description

In this study, ten anthra-, nine naphtho-, and five benzoquinone compounds of natural origin and five synthetic naphthoquinones were assessed, using an enzymatic in vitro assay, for their potential to inhibit cyclooxygenase-1 and -2 (COX-1 and COX-2), the key enzymes of the arachidonic acid cascade. IC50 values comparable with COX reference inhibitor indomethacin were recorded for several quinones (primin, alkannin, diospyrin, juglone, 7-methyljuglone, and shikonin). For some of the compounds, we suggest that the redox potential of quinones as the mechanisms responsible for in vitro COX inhibition because of quantitative correlation with their pro-oxidant effect. Structure-relationship activity studies revealed that the substitutions at positions 2 and5 play the key roles in the COX inhibitory and pro-oxidant actions of naphthoquinones. In contrast, the redox mechanism alone could not explain activity of primin, embelin, alkannin, and diospyrin. For these four quinones, molecular mode

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GM - Food industry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Planta medica

ISSN

0032-0943

e-ISSN

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Volume of the periodical

78

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

326-333

UT code for WoS article

000301343700005

EID of the result in the Scopus database

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