The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191499" target="_blank" >RIV/00216208:11310/13:10191499 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/13:00396249

Result on the web

<a href="http://dx.doi.org/10.1002/jez.b.22502" target="_blank" >http://dx.doi.org/10.1002/jez.b.22502</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jez.b.22502" target="_blank" >10.1002/jez.b.22502</a>

Result language

angličtina

Original language name

The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

Original language description

In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

<a href="/en/project/GAP305%2F12%2F1766" target="_blank" >GAP305/12/1766: Rudiments in the mouse model of tooth development</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

ISSN

1552-5007

e-ISSN

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Volume of the periodical

320B

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

307-320

UT code for WoS article

000320170600006

EID of the result in the Scopus database

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