Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10297680" target="_blank" >RIV/00216208:11310/15:10297680 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/15:00450100
Result on the web
<a href="http://dx.doi.org/10.1186/s12861-015-0070-0" target="_blank" >http://dx.doi.org/10.1186/s12861-015-0070-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12861-015-0070-0" target="_blank" >10.1186/s12861-015-0070-0</a>

Result language
angličtina
Original language name
Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation
Original language description
Background: The mouse embryonic mandible comprises two types of tooth primordia in the cheek region: progressive tooth primordia of prospective functional teeth and rudimentary tooth primordia in premolar region - MS and R2. Mice lacking Sprouty genes develop supernumerary tooth in front of the lower M1 (first molar) primordium during embryogenesis. We focused on temporal-spatial dynamics of Sonic Hedgehog expression as a marker of early odontogenesis during supernumerary tooth development. Results: Using mouse embryos with different dosages of Spry2 and Spry4 genes, we showed that during the normal development of M1 in the mandible the sooner appearing Shh signaling domain of the R2 bud transiently coexisted with the later appearing Shh expression domain in the early M1 primordium. Both domains subsequently fused together to form the typical signaling center representing primary enamel knot (pEK) of M1 germ at embryonic day (E) 14.5. However, in embryos with lower Spry2; Spry4 gene do
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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