Perspectives and industrial potential of PGA selectivity and promiscuity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191753" target="_blank" >RIV/00216208:11310/13:10191753 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.biotechadv.2013.07.005" target="_blank" >http://dx.doi.org/10.1016/j.biotechadv.2013.07.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biotechadv.2013.07.005" target="_blank" >10.1016/j.biotechadv.2013.07.005</a>
Alternative languages
Result language
angličtina
Original language name
Perspectives and industrial potential of PGA selectivity and promiscuity
Original language description
Penicillin G acylases (PGAs) are robust industrial catalysts used for biotransformation of ?-lactams into key intermediates for chemical production of semi-synthetic ?-lactam antibiotics by hydrolysis of natural penicillins. They are used also in reverse, kinetically controlled synthetic reactions for large-scale productions of these antibiotics from corresponding beta-lactam nuclei and activated acyl donors. Further biocatalytic applications of PGAs have recently been described: catalysis of peptide syntheses and the resolutions of racemic mixtures for the production of enantiopure active pharmaceutical ingredients that are based on enantioselective acylation or chiral hydrolysis. Moreover, PGAs rank among promiscuous enzymes because they also catalyze reactions such as trans-esterification, Markovnikov addition or Henry reaction. This particular biocatalytic versatility represents a driving force for the discovery of novel members of this enzyme family and further research into the c
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biotechnology Advances
ISSN
0734-9750
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
15
Pages from-to
1458-1472
UT code for WoS article
000329081200026
EID of the result in the Scopus database
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