Current state and perspectives of penicillin G acylase-based biocatalyses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10289021" target="_blank" >RIV/00216208:11310/14:10289021 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/14:00435793

Result on the web

<a href="http://dx.doi.org/10.1007/s00253-013-5492-7" target="_blank" >http://dx.doi.org/10.1007/s00253-013-5492-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00253-013-5492-7" target="_blank" >10.1007/s00253-013-5492-7</a>

Result language

angličtina

Original language name

Current state and perspectives of penicillin G acylase-based biocatalyses

Original language description

In the course of more than 60-year history, penicillin G acylase (PGA) gained a unique position among enzymes used by pharmaceutical industry for production of beta-lactam antibiotics. Kinetically controlled enzymatic syntheses of cephalosporins of novelgenerations in which PGA catalyzes coupling of activated acyl donor with nucleophile belong among the latest large-scale applications. Contrary to rather specific roles of other enzymes involved in beta-lactam biocatalyses, the PGA seems to have the greatest potential. On the laboratory scale, other applications with industrial potential were described, e.g., directed evolution of the enzyme to meet specific demands of industrial processes or its modification into the enzyme catalyzing reactions with novel substrates. The fact that beta-lactams represent the most important group of antibiotics comprising 65 % of the world antibiotic market explains such a tremendous and continuous interest in this enzyme. Indeed, the annual consumption

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Microbiology and Biotechnology

ISSN

0175-7598

e-ISSN

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Volume of the periodical

98

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

2867-2879

UT code for WoS article

000334167900003

EID of the result in the Scopus database

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