Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10196792" target="_blank" >RIV/00216208:11310/14:10196792 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/14:00433504 RIV/61388963:_____/14:00433504

Result on the web

<a href="http://link.springer.com/article/10.1007/s12104-013-9531-1" target="_blank" >http://link.springer.com/article/10.1007/s12104-013-9531-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12104-013-9531-1" target="_blank" >10.1007/s12104-013-9531-1</a>

Result language

angličtina

Original language name

Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

Original language description

We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme isresponsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomolecular NMR Assignments

ISSN

1874-2718

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

425-428

UT code for WoS article

000342080900042

EID of the result in the Scopus database

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