Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F04%3A00011790" target="_blank" >RIV/60461373:22310/04:00011790 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model
Original language description
Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition.
Czech name
Design, syntéza a studium modelu fotolyasy
Czech description
Design, syntéza a studium modelu fotolyasy

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)