Morphological analysis of embryonic cerebellar grafts in SCA2 mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10210639" target="_blank" >RIV/00216208:11310/14:10210639 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/14:10210639

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0304394013010203#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0304394013010203#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2013.11.020" target="_blank" >10.1016/j.neulet.2013.11.020</a>

Result language

angličtina

Original language name

Morphological analysis of embryonic cerebellar grafts in SCA2 mice

Original language description

SCA2 transgenic mice are thought to be a useful model of human spinocerebellar ataxia type 2. There is no effective therapy for cerebellar degenerative disorders, therefore neurotransplantation could offer hope. The aim of this work was to assess the survival and morphology of embryonic cerebellar grafts transplanted into the cerebellum of adult SCA2 mice. Four month-old homozygous SCA2 and negative control mice were treated with bilateral intracerebellar injections of an enhanced green fluorescent protein-positive embryonic cerebellar cell suspension. Graft survival and morphology were examined three months later. Graft-derived Purkinje cells and the presence of astrocytes in the graft were detected immunohistochemically. Nissl and hematoxylin-eosin techniques were used to visualize the histological structure of the graft and surrounding host tissue. Grafts survived in all experimental mice; no differences in graft structure, between SCA2 homozygous and negative mice, were found. The

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/LD12056" target="_blank" >LD12056: Neurotransplantation therapy in the mouse model of spinocerebellar ataxia type 2</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Volume of the periodical

558

Issue of the periodical within the volume

January

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

154-158

UT code for WoS article

000338481300029

EID of the result in the Scopus database

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