Voltammetric Study of dsDNA Modified by Multi-redox Label Based on N-methyl-4-hydrazino-7-nitrobenzofurazan

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10218662" target="_blank" >RIV/00216208:11310/14:10218662 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00435356 RIV/61388963:_____/14:00435356 RIV/00216224:14740/14:00073590
Result on the web
<a href="http://dx.doi.org/10.1016/j.electacta.2014.02.137" target="_blank" >http://dx.doi.org/10.1016/j.electacta.2014.02.137</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.electacta.2014.02.137" target="_blank" >10.1016/j.electacta.2014.02.137</a>

Result language
angličtina
Original language name
Voltammetric Study of dsDNA Modified by Multi-redox Label Based on N-methyl-4-hydrazino-7-nitrobenzofurazan
Original language description
Voltammetric behaviour of novel synthetic multi-redox DNA label N-methyl-4-hydrazino-7-nitrobenzofurazan (NBF), a deoxycytidine monophosphate conjugate with NBF via formylthiophene linker (dC(NBF)MP), and NBF labeled model short double stranded DNA (dsDNA-NBF) were systematically studied at mercury meniscus modified silver solid amalgam electrode (m-AgSAE) for the first time in this work. Successful enzymatic incorporation of the NBF labeled deoxycytidine triphosphate into the DNA was confirmed and thedsDNA-NBF offered new more positive cathodic signals at -520 mV and 1160 mV, compared to the nucleic acid itself. Used modification resulted in increase of selectivity and sensitivity of the DNA voltammetric determination. Next to the pioneering voltammetric behaviour of all studied compounds at m-AgSAE, electroanalytical methods based on cyclic voltammetry, adsorptive stripping cyclic voltammetry and open circuit transfer stripping cyclic voltammetry were developed for sensitive detecti
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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