Electrochemical behaviour of 2,4-dinitrophenylhydrazi(o)ne as multi-redox centre DNA label at mercury meniscus modified silver solid amalgam electrode

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10271946" target="_blank" >RIV/00216208:11310/14:10271946 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00435150 RIV/61388963:_____/14:00435150 RIV/00216224:14740/14:00073589
Result on the web
<a href="http://dx.doi.org/10.1016/j.electacta.2013.09.147" target="_blank" >http://dx.doi.org/10.1016/j.electacta.2013.09.147</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.electacta.2013.09.147" target="_blank" >10.1016/j.electacta.2013.09.147</a>

Result language
angličtina
Original language name
Electrochemical behaviour of 2,4-dinitrophenylhydrazi(o)ne as multi-redox centre DNA label at mercury meniscus modified silver solid amalgam electrode
Original language description
A detailed voltammetric study of 2,4-dinitrophenylhydrazine (DNPH), a DNPH modified nucleotide (dC(DNPH)MP) and a short single stranded DNA (ssDNA-DNPH) at mercury meniscus modified silver solid amalgam electrode (m-AgSAE) is presented in this work. Electrochemical behaviour of these compounds was studied using cyclic voltammetry (CV), adsorptive stripping CV and open circuit adsorptive transfer stripping CV. Adsorptive and transfer stripping techniques offered sensitive detection of the studied compounds at submicromolar levels with low sample volume consumption (about 0.5 mu l), respectively. The ssDNA-DNPH gives three specific cathodic signals related to the reduction of the redox label. All these signals advantageously appear at significantly lessnegative potentials than unmodified nucleic acid and they may be optionally switched on/off by properly adjusted potential windows and scan rates. This opportunity increases signal response diversity and selectivity in DNA sensing. Mechan
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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