Square wave voltammetry as a tool for study of ellipticine-DNA interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F10%3APU99543" target="_blank" >RIV/00216305:26220/10:PU99543 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Square wave voltammetry as a tool for study of ellipticine-DNA interaction
Original language description
Ellipticine and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytostaic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observedas a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů