Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10218674" target="_blank" >RIV/00216208:11310/14:10218674 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0021967314009649/1-s2.0-S0021967314009649-main.pdf?_tid=a08e9c2c-a563-11e4-9b5e-00000aab0f02&acdnat=1422280984_678c9a6ddb67419a5eabff83ae8279b0" target="_blank" >http://ac.els-cdn.com/S0021967314009649/1-s2.0-S0021967314009649-main.pdf?_tid=a08e9c2c-a563-11e4-9b5e-00000aab0f02&acdnat=1422280984_678c9a6ddb67419a5eabff83ae8279b0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chroma.2014.06.040" target="_blank" >10.1016/j.chroma.2014.06.040</a>

Result language
angličtina
Original language name
Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode
Original language description
Derivatized polysaccharide-based columns have high enantiodiscrimination potential mainly in normal phase separation mode. In this work chiral recognition ability of four immobilized polysaccharide-derived chiral stationary phases was evaluated under reversed phase conditions. A set of 30 chiral compounds, particularly drugs possessing various functional groups was used for testing. Baseline enantioseparation was achieved for 17 of them. In general, amylose-based chiral stationary phases showed higher enantio- selectivity than the cellulose-based ones, mainly for acidic and bifunctional compounds. The influence of the type and pH of the aqueous mobile phase constituents a well as the role of the organic modifier on the enantioselective separation ability of the stationary phases were also investigated and compared. Com- plementary separations were obtained on the amylose- and cellulose-based columns. The immobilized polysaccharide-based chiral stationary phases were shown to be useful
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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