Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10293125" target="_blank" >RIV/00216208:11310/15:10293125 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs10337-014-2804-8" target="_blank" >http://link.springer.com/article/10.1007%2Fs10337-014-2804-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-014-2804-8" target="_blank" >10.1007/s10337-014-2804-8</a>

Result language

angličtina

Original language name

Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

Original language description

A set of 31 structurally different chiral pharmaceutical compounds was used as model analytes for investigation of the enantioselective potential of two immobilized polysaccharide-based chiral stationary phases under normal and reversed phase separationconditions. These chiral stationary phases differed in the polymeric backbone, amylose or cellulose, but possessed the same derivatization functionality. The results showed that the tris(3,5-dimethylphenylcarbamate) of amylose and cellulose have very broad, and often complementary, enantiorecognition abilities. In general, normal phase separation mode seemed to be more advantageous for separation of the majority of studied pharmaceuticals no matter if amylose- or cellulose-based columns were used. However, in certain cases the reversed phase separation system yielded better results. The combination of these two immobilized chiral stationary phases offers a powerful tool for enantioseparation of different types of pharmaceuticals in the

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/LH11018" target="_blank" >LH11018: Cyclofructans and their derivatives as new chiral selectors for liquid chromatography and capillary electrophoresis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chromatographia

ISSN

0009-5893

e-ISSN

—

Volume of the periodical

79

Issue of the periodical within the volume

13-14

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

909-915

UT code for WoS article

000357460300008

EID of the result in the Scopus database

2-s2.0-84943350557