Comparative Analysis of Salivary Gland Transcriptomes of Phlebotomus orientalis Sand Flies from Endemic and Non-endemic Foci of Visceral Leishmaniasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10227341" target="_blank" >RIV/00216208:11310/14:10227341 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pntd.0002709" target="_blank" >http://dx.doi.org/10.1371/journal.pntd.0002709</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0002709" target="_blank" >10.1371/journal.pntd.0002709</a>
Alternative languages
Result language
angličtina
Original language name
Comparative Analysis of Salivary Gland Transcriptomes of Phlebotomus orientalis Sand Flies from Endemic and Non-endemic Foci of Visceral Leishmaniasis
Original language description
Two cDNA libraries were constructed from female salivary glands of P. orientalis from Addis Zemen and Melka Werer. Phylogenetic analysis were performed to evaluate differences between the P. orientalis colonies and to show the relationship with other sand fly species from the subgenus Larroussius. we investigated the humoral antigenicity and cross-reactivity of the salivary proteins and the activity of salivary apyrase and hyaluronidase. Our study expanded the knowledge of salivary gland compounds of sand fly species in the subgenus Larroussius. we showed that P. orientalis is closely related to Phlebotomus tobbi and Phlebotomus perniciosus, whereas Phlebotomus ariasi is evolutionarily more distinct species. We demonstrated that there is no significantdifference between the transcriptomes, proteomes or enzymatic properties of the salivary components of Addis Zemen and Melka Werer. Thus, the different epidemiology of VL in these Ethiopian foci cannot be attributed to the salivary gland
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-05292S" target="_blank" >GA13-05292S: Phlebotomus orientalis: salivary proteins and the host antibody response</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Neglected Tropical Diseases [online]
ISSN
1935-2735
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
19
Pages from-to
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UT code for WoS article
000332017500009
EID of the result in the Scopus database
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