Structural Basis for Antimicrobial Activity of Lasiocepsin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10283812" target="_blank" >RIV/00216208:11310/14:10283812 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/14:00427641
Result on the web
<a href="http://dx.doi.org/10.1002/cbic.201300509" target="_blank" >http://dx.doi.org/10.1002/cbic.201300509</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.201300509" target="_blank" >10.1002/cbic.201300509</a>
Alternative languages
Result language
angličtina
Original language name
Structural Basis for Antimicrobial Activity of Lasiocepsin
Original language description
Lasiocepsin is a unique 27-residue antimicrobial peptide, isolated from Lasioglossum laticeps (wild bee) venom, with substantial antibacterial and antifungal activity. It adopts a welldefined structure consisting of two -helices linked by a structured loop. Its basic residues form two distinct positively charged regions on the surface whereas aliphatic side chains contribute to solvent-accessible hydrophobic areas, thus emphasising the amphipathic character of the molecule. Lasiocepsin structurally belongs to the ShK family and shows a strong preference for anionic phospholipids; this is further augmented by increasing concentrations of cardiolipin, such as those found at the poles of bacterial cells. The membrane-permeabilising activity of the peptideis not limited to outer membranes of Gram-negative bacteria. The peptide interacts with phospholipids initially through its N terminus, and its degree of penetration is strongly dependent on the presence of cardiolipin.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chembiochem : a European journal of chemical biology
ISSN
1439-4227
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
301-308
UT code for WoS article
000329877400016
EID of the result in the Scopus database
—