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Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-gamma-Treated Mesenchymal Stromal Cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10285610" target="_blank" >RIV/00216208:11310/14:10285610 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1089/scd.2013.0568" target="_blank" >http://dx.doi.org/10.1089/scd.2013.0568</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/scd.2013.0568" target="_blank" >10.1089/scd.2013.0568</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-gamma-Treated Mesenchymal Stromal Cells

  • Original language description

    The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24 h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1 alpha (IL-1 alpha), transforming growth factor-beta (TGF-beta), or interferon-gamma (IFN-gamma). Analysisof cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with controleyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-gamm

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Stem Cells and Development

  • ISSN

    1547-3287

  • e-ISSN

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    20

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    2490-2500

  • UT code for WoS article

    000342614300008

  • EID of the result in the Scopus database