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Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats - A Comparative Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286773" target="_blank" >RIV/00216208:11310/14:10286773 - isvavai.cz</a>

  • Alternative codes found

    RIV/62156489:43210/14:00230443

  • Result on the web

    <a href="http://dx.doi.org/10.3390/s141222982" target="_blank" >http://dx.doi.org/10.3390/s141222982</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/s141222982" target="_blank" >10.3390/s141222982</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats - A Comparative Study

  • Original language description

    The requirements for early diagnostics as well as effective treatment of cancer diseases have increased the pressure on development of efficient methods for targeted drug delivery as well as imaging of the treatment success. One of the most recent approaches covering the drug delivery aspects is benefitting from the unique properties of nanomaterials. Ellipticine and its derivatives are efficient anticancer compounds that function through multiple mechanisms. Formation of covalent DNA adducts after ellipticine enzymatic activation is one of the most important mechanisms of its pharmacological action. In this study, we investigated whether ellipticine might be released from its micellar (encapsulated) form to generate covalent adducts analogous to thoseformed by free ellipticine. The 32P-postlabeling technique was used as a useful imaging method to detect and quantify covalent ellipticine-derived DNA adducts. We compared the efficiencies of free ellipticine and its micellar form (the p

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA14-18344S" target="_blank" >GA14-18344S: Development of nanoparticle-based cytostatics and enzymes for enhanced chemotherapy of human neuroblastomas and study of mechanisms of their action</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Sensors

  • ISSN

    1424-8220

  • e-ISSN

  • Volume of the periodical

    14

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    16

  • Pages from-to

    22982-22997

  • UT code for WoS article

    000346794300043

  • EID of the result in the Scopus database