Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats - A Comparative Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286773" target="_blank" >RIV/00216208:11310/14:10286773 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/14:00230443
Result on the web
<a href="http://dx.doi.org/10.3390/s141222982" target="_blank" >http://dx.doi.org/10.3390/s141222982</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/s141222982" target="_blank" >10.3390/s141222982</a>
Alternative languages
Result language
angličtina
Original language name
Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats - A Comparative Study
Original language description
The requirements for early diagnostics as well as effective treatment of cancer diseases have increased the pressure on development of efficient methods for targeted drug delivery as well as imaging of the treatment success. One of the most recent approaches covering the drug delivery aspects is benefitting from the unique properties of nanomaterials. Ellipticine and its derivatives are efficient anticancer compounds that function through multiple mechanisms. Formation of covalent DNA adducts after ellipticine enzymatic activation is one of the most important mechanisms of its pharmacological action. In this study, we investigated whether ellipticine might be released from its micellar (encapsulated) form to generate covalent adducts analogous to thoseformed by free ellipticine. The 32P-postlabeling technique was used as a useful imaging method to detect and quantify covalent ellipticine-derived DNA adducts. We compared the efficiencies of free ellipticine and its micellar form (the p
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA14-18344S" target="_blank" >GA14-18344S: Development of nanoparticle-based cytostatics and enzymes for enhanced chemotherapy of human neuroblastomas and study of mechanisms of their action</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sensors
ISSN
1424-8220
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
22982-22997
UT code for WoS article
000346794300043
EID of the result in the Scopus database
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