Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10287597" target="_blank" >RIV/00216208:11310/14:10287597 - isvavai.cz</a>

Alternative codes found

RIV/68081766:_____/14:00434859

Result on the web

<a href="http://dx.doi.org/10.1186/s12711-014-0072-6" target="_blank" >http://dx.doi.org/10.1186/s12711-014-0072-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12711-014-0072-6" target="_blank" >10.1186/s12711-014-0072-6</a>

Result language

angličtina

Original language name

Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds

Original language description

Background: Toll-like receptors (TLR) are essential activators of the innate part of the vertebrate immune system. In this study, we analysed the interspecific variability of three TLR (bacterial-sensing TLR4 and TLR5 and viral-sensing TLR7) within the Galloanserae bird clade, investigated their phylogeny, assessed their structural conservation and estimated site-specific selection pressures. Results: Physiochemical properties varied according to the TLR analysed, mainly with regards to the surface electrostatic potential distribution. The predicted ligand-binding features (mainly in TLR4 and TLR5) differed between the avian proteins and their fish and mammalian counterparts, but also varied within the Galloanserae birds. We identified 20 positively selected sites in the three TLR, among which several are topologically close to ligand-binding sites reported for mammalian and fish TLR. We described 26, 28 and 25 evolutionarily non-conservative sites in TLR4, TLR5 and TLR7, respectively.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genetics, Selection, Evolution

ISSN

0999-193X

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

72

Country of publishing house

FR - FRANCE

Number of pages

12

Pages from-to

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UT code for WoS article

000347079900001

EID of the result in the Scopus database

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