Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10288747" target="_blank" >RIV/00216208:11310/14:10288747 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00437874
Result on the web
<a href="http://dx.doi.org/10.3389/fncel.2014.00375" target="_blank" >http://dx.doi.org/10.3389/fncel.2014.00375</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fncel.2014.00375" target="_blank" >10.3389/fncel.2014.00375</a>
Alternative languages
Result language
angličtina
Original language name
Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors
Original language description
N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. The activation of NMDA receptors plays a key role in brain development, synaptic plasticity, and memory formation, and is a majorcontributor to many neuropsychiatric disorders. Here, we investigated the mechanisms that underlie the trafficking of GluN1/GluN2C receptors. Using an approach combining molecular biology, microscopy, and electrophysiology in mammalian cell lines and cultured cerebellar granule cells, we found that the surface delivery of GluN2C-containing receptors is reduced compared to GluN2A- and GluN2B-containing receptors. Furthermore, we identified three distinct regions within the N-terminus, M3 transmembrane domain, and C-terminus of GluN2C subunits that are required for proper intracellular processing and surface delivery of NMDA receptors. These results shed new light on the regulation of NMDA receptor trafficking, and these findings can be
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular Neuroscience
ISSN
1662-5102
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
November
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
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UT code for WoS article
000344540900001
EID of the result in the Scopus database
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