Preparation of silybin phase II metabolites: Streptomyces catalyzed glucuronidation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10289023" target="_blank" >RIV/00216208:11310/14:10289023 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00435567
Result on the web
<a href="http://dx.doi.org/10.1016/j.molcatb.2014.02.008" target="_blank" >http://dx.doi.org/10.1016/j.molcatb.2014.02.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molcatb.2014.02.008" target="_blank" >10.1016/j.molcatb.2014.02.008</a>

Result language
angličtina
Original language name
Preparation of silybin phase II metabolites: Streptomyces catalyzed glucuronidation
Original language description
Flavonolignan silybin is a major component of the silymarin complex isolated from seeds of the milk thistle (Silybum marianum) having strong antioxidant and hepatoprotective effects, and also anticancer, chemoprotective, dermatoprotective and hypocholesterolemic activities. Natural silybin (silibinin in pharmacological literature) is a mixture of two diastereomers: silybin A and silybin B. Their metabolism is strongly linked to Phase II biotransformations and respective conjugates are rapidly excreted in bile and urine. Conjugation reactions of both silybins are strictly stereoselective. Therefore, optically pure compounds must be used for metabolic studies. The aim of this study was to obtain the glucuronidated metabolites of both silybin A and B. Streptomyces sp. strain M52104 was found to be a highly effective tool for the preparation of silybin A-20-O-beta-glucuronide, silybin B-20-O-beta-glucuronide, silybin glucuronide and silybin B-7-O-beta-glucuronide and minor amounts of silyb
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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