The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F10%3A63510150" target="_blank" >RIV/70883521:28110/10:63510150 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review
Original language description
Silymarin, a standard extract from Silybum marianum L. seeds, contains at least 7 flavonolignans and flavonoid taxifolin. It has been used to date, as a hepatoprotectant and chemoprotectant. Flavonolignan silybin, the main component of silymarin, is composed of two diastereomers A and B in an approximately 1:1 ratio. Silybin can inhibit the activities of cytochrome P450 enzymes (CYP) (Beckmann-Knopp S. et al., 2000). In our study, the most prominent inhibition effect was found with CYP3A4 and CYP2C9 (IC50 <= 50 ?M). In the second part of our study, the metabolism of silybin in vitro was analyzed in detail. The results indicated that silybin is subjected to O-demethylation by CYP2C8, enzymes of Phase I in xenobiotic metabolism. The contribution of UDP-glucuronosyltransferases (main phase II enzymes) to the metabolism of silybin and its A and B diastereomers was also investigated. Four main metabolites of silybin, namely silybin A-7-O-?-D-glucuronide, B-7-O-?-D-glucuronide, A-20-O
Czech name
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Czech description
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Biomedical Papers of the Faculty of Medicine of Palacký University in Olomouc
ISBN
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ISSN
1213-8118
e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
Univerzita Palackého v Olomouci
Place of publication
Olomouc
Event location
Vyškov
Event date
Jan 1, 2010
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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