Adaptation to continuous and intermittent normobaric hypoxia is associated with similar alterations in the myocardial ?-adrenergic signaling system

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10290404" target="_blank" >RIV/00216208:11310/14:10290404 - isvavai.cz</a>
Result on the web
<a href="http://cardiologyacademicpress.com/soap/pdf/delme_2504_540f7d146d1a78.95763896.pdf" target="_blank" >http://cardiologyacademicpress.com/soap/pdf/delme_2504_540f7d146d1a78.95763896.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Adaptation to continuous and intermittent normobaric hypoxia is associated with similar alterations in the myocardial ?-adrenergic signaling system
Original language description
Adaptation to chronic hypoxia can protect the heart against acute ischemic injury under certain conditions. However, the molecular mechanisms engaged in adaptive changes of the heart are still not well understood. Here we assessed the effects of adaptation to 3-week continuous (CNH) or intermittent normobaric hypoxia (INH; 23 h hypoxia followed by 1 h reoxygenation) on ?-adrenergic signaling in the rat myocardium. Exposure to both regimens of hypoxia resulted in loss of body weight and marked right ventricular (RV) hypertrophy. Whereas there was no significant change in ?-adrenoceptors (?-ARs) in the left ventricles (LV), the total number of these receptors was reduced by about 25% in RV preparations from animals adapted to hypoxia. Discrimination of ?-AR receptor subtypes indicated that the diminution of these receptors was largerly attributable to the loss of ?1-ARs. Chronic hypoxia did not substantially influence the expression of the dominant isoforms of myocardial adenylyl cyclase
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F12%2F1162" target="_blank" >GAP303/12/1162: Interaction between sustained forms of cardioprotection induced by adaptation to chronic hypoxia and regular exercise training.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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