Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation: Thermodynamic and Kinetic Studies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10294028" target="_blank" >RIV/00216208:11310/15:10294028 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/15:00442242
Result on the web
<a href="http://dx.doi.org/10.1002/chem.201405777" target="_blank" >http://dx.doi.org/10.1002/chem.201405777</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201405777" target="_blank" >10.1002/chem.201405777</a>

Result language
angličtina
Original language name
Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation: Thermodynamic and Kinetic Studies
Original language description
Two macrocyclic ligands based on cyclam with trans-disposed N-methyl and N-(4-aminobenzyl) substituents as well as two methylphosphinic (H(2)L1) or methylphosphonic (H(4)L2) acid pendant arms were synthesised and investigated in solution. The ligands form stable complexes with transition metal ions. Both ligands show high thermodynamic selectivity for divalent copper over nickel(II) and zinc(II)K(CuL) is larger than K(Ni/ZnL) by about seven orders of magnitude. Complexation is significantly faster for the phosphonate ligand H(4)L2, probably due to the stronger coordination ability of the more basic phosphonate groups, which efficiently bind the metal ion in an out-of-cage complex and thus accelerate its in-cage binding. The rate of Cu-II complexation by the phosphinate ligand H(2)L1 is comparable to that of cyclam itself and its derivatives with non-coordinating substituents. Acid-assisted decomplexation of the copper(II) complexes is relatively fast ((1/2)=44 and 42s in 1M aq. HClO4 a
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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