Complexes of NOTA-Monoamides with Cu(II) Ions: Structural, Equilibrium, and Kinetic Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10447175" target="_blank" >RIV/00216208:11310/22:10447175 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00125996
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=B04BUjZD63" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=B04BUjZD63</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejic.202200173" target="_blank" >10.1002/ejic.202200173</a>
Alternative languages
Result language
angličtina
Original language name
Complexes of NOTA-Monoamides with Cu(II) Ions: Structural, Equilibrium, and Kinetic Study
Original language description
NOTA monoamides are commonly and widely used chelators for the complexation of copper radioisotopes applied in molecular imaging and targeted nuclear therapy. However, information about their coordination behavior remains scarce. In this study, two NOTA-monoamides, N-ethyl (H(2)L1) and N,N-diethyl (H(2)L2), were synthesized as model ligands and tested to probe differences in their coordination behavior between the secondary and tertiary amide pendant arms for potential applications as copper radioisotope carriers. Our results demonstrated that the solid [Cu(L1)] and [Cu(L2)] complex have a distorted octahedral arrangement, similar to structure of the [Cu(Hnota)] complex. As shown by equilibrium data, the ligands have a slightly lower basicity, and thus complexes with divalent metal ions and Li(I) have slightly lower stability constants than those of the parent ligand, H(3)nota. The dissociation constants of the Cu(II), Zn(II) and Ni(II) complexes with H(2)L1 also indicate deprotonation and N-coordination of the secondary amide group at pH>9. Complexation of Cu(II) ions with the title ligands is slower than that with H3nota but still very fast (quantitative binding in <1 s, pH 2, millimolar concentrations), and Cu(II) complexes of both monoamide ligands are more resistant to acid-assisted decomplexation than the Cu(II)-H(3)nota complex. Therefore, our coordination data highlight that NOTA-monoamides are suitable chelators for molecular imaging and nuclear medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Inorganic Chemistry
ISSN
1434-1948
e-ISSN
1099-0682
Volume of the periodical
2022
Issue of the periodical within the volume
19
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
e202200173
UT code for WoS article
000807727100001
EID of the result in the Scopus database
2-s2.0-85131583434