Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296111" target="_blank" >RIV/00216208:11310/15:10296111 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/cmmi.1606" target="_blank" >http://dx.doi.org/10.1002/cmmi.1606</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmmi.1606" target="_blank" >10.1002/cmmi.1606</a>

Result language
angličtina
Original language name
Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging
Original language description
Ligands with geminal bis(phosphonic acid) appended to 1,4,7-triazacyclonone-1,4-diacetic acid fragment through acetamide (NOTAM(BP)) or methylenephosphinate (NO2AP(BP)) spacers designed for Ga-68 were prepared. Ga-III complexation is much faster for ligand with methylenephosphinate spacer than that with acetamide one, in both chemical (high reactant concentrations) and radiolabeling studies with no-carrier-added Ga-68. For both ligands, formation of Ga-III complex was slower than that with NOTA owing tothe strong out-of-cage binding of bis(phosphonate) group. Radiolabeling was efficient and fast only above 60 degrees C and in a narrow acidity region (pH similar to 3). At higher temperature, hydrolysis of amide bond of the carboxamide-bis(phosphonate)conjugate was observed during complexation reaction leading to Ga-NOTA complex. In vitro sorption studies confirmed effective binding of the Ga-68 complexes to hydroxyapatite being comparable with that found for common bis(phosphonate) dr
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-08336S" target="_blank" >GA13-08336S: Hybrid materials based on macrocyclic ligands for medical applications</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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