Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10089979" target="_blank" >RIV/00216208:11310/11:10089979 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1524/ract.2011.1791" target="_blank" >http://dx.doi.org/10.1524/ract.2011.1791</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1524/ract.2011.1791" target="_blank" >10.1524/ract.2011.1791</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism
Original language description
Tc-99m-phosphonate structures are well established tracers for bone tumour imaging. Our objective was to investigate different Ga-68-labelled phosphonate ligands concerning labelling kinetics, binding to hydroxyapatite and bone imaging using mu-PET. Seven macrocyclic phosphorus-containing ligands and EDTMP were labelled in nanomolar scale with n.c.a. Ga-68 in Na-HEPES buffer at pH similar to 4. Except for DOTP, all ligands were labelled with } 92% yield. Binding of the Ga-68-ligand complexes on hydroxyapatite was analysed to evaluate the effect of the number of the phosphorus acid groups on adsorption parameters. Adsorption of Ga-68-EDTMP and Ga-68-DOTP was } 83%. For the Ga-68-NOTA-phosphonates an increasing binding with increasing number of phosphonate groups was observed but was still lower than Ga-68-DOTP and Ga-68-EDTMP. mu-PET studies in vivo were performed with Ga-68-EDTMP and Ga-68-DOTP with Wistar rats. While Ga-68-EDTMP-PET showed uptake on bone structures, an excess amount o
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiochimica Acta
ISSN
0033-8230
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
43-51
UT code for WoS article
000286917000007
EID of the result in the Scopus database
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