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Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10089979" target="_blank" >RIV/00216208:11310/11:10089979 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1524/ract.2011.1791" target="_blank" >http://dx.doi.org/10.1524/ract.2011.1791</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1524/ract.2011.1791" target="_blank" >10.1524/ract.2011.1791</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism

  • Original language description

    Tc-99m-phosphonate structures are well established tracers for bone tumour imaging. Our objective was to investigate different Ga-68-labelled phosphonate ligands concerning labelling kinetics, binding to hydroxyapatite and bone imaging using mu-PET. Seven macrocyclic phosphorus-containing ligands and EDTMP were labelled in nanomolar scale with n.c.a. Ga-68 in Na-HEPES buffer at pH similar to 4. Except for DOTP, all ligands were labelled with } 92% yield. Binding of the Ga-68-ligand complexes on hydroxyapatite was analysed to evaluate the effect of the number of the phosphorus acid groups on adsorption parameters. Adsorption of Ga-68-EDTMP and Ga-68-DOTP was } 83%. For the Ga-68-NOTA-phosphonates an increasing binding with increasing number of phosphonate groups was observed but was still lower than Ga-68-DOTP and Ga-68-EDTMP. mu-PET studies in vivo were performed with Ga-68-EDTMP and Ga-68-DOTP with Wistar rats. While Ga-68-EDTMP-PET showed uptake on bone structures, an excess amount o

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CA - Inorganic chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Radiochimica Acta

  • ISSN

    0033-8230

  • e-ISSN

  • Volume of the periodical

    99

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    9

  • Pages from-to

    43-51

  • UT code for WoS article

    000286917000007

  • EID of the result in the Scopus database