In vivo comparison of DOTA based Ga-68-labelled bisphosphonates for bone imaging in non-tumour models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10139597" target="_blank" >RIV/00216208:11310/13:10139597 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2013.04.012" target="_blank" >http://dx.doi.org/10.1016/j.nucmedbio.2013.04.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2013.04.012" target="_blank" >10.1016/j.nucmedbio.2013.04.012</a>

Result language
angličtina
Original language name
In vivo comparison of DOTA based Ga-68-labelled bisphosphonates for bone imaging in non-tumour models
Original language description
Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous Tc-88m-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both Ga-68 mu-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with Ga-68 in high yields using an ammonium acetate buffer, and subsequently purified using a cation exchange resin. High bone uptake values were observed for all Ga-68-labelled bisphosphonates at 60 minutes p.i. The highest uptake was observed for [Ga-68]BPPED (2.6 +/- 0.3% ID/g) which compares favourably
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
—

Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)