Ga-68-BPAMD: PET-imaging of bone metastases with a generator based positron emitter

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10124831" target="_blank" >RIV/00216208:11310/12:10124831 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2012.04.007" target="_blank" >http://dx.doi.org/10.1016/j.nucmedbio.2012.04.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2012.04.007" target="_blank" >10.1016/j.nucmedbio.2012.04.007</a>

Result language
angličtina
Original language name
Ga-68-BPAMD: PET-imaging of bone metastases with a generator based positron emitter
Original language description
Purpose: Bone metastases are a serious aggravation for patients suffering from cancer. Therefore, early recognition of bone metastases is of great interest for further treatment of patients. Bisphosphonates are widely used for scintigraphy of bone lesions with Tc-99m. Using the Ge-68/Ga-68 generator together with a macroyclic bisphosphonate a comparable PET-tracer comes into focus. Procedures: The bisphosphonate DOTA-conjugated ligand BPAMD was labelled with Ga-68. [Ga-68]BPAMD was evaluated in vitro concerning binding to hydroxyapatite and stability. The tracer's in vivo accumulation was determined on healthy rats and bone metastases bearing animals by mu-PET. Results: BPAMD was labelled efficiently with 68Ga after 10 min at 100 degrees C. [Ga-68]BPAMD allowed high in vitro stability within 3 h and high binding to hydroxyapatite. Consequently, mu-PET experiments revealed high accumulation of [Ga-68]BPAMD in regions of pronounced remodelling activity like bone metastases. Conclusions:
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
<a href="/en/project/OC%20179" target="_blank" >OC 179: Metal-based systems for molecular imaging applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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