Chemistry of cobalt bis(1,2-dicarbollide) ion; the synthesis of carbon substituted alkylamino derivatives from hydroxyalkyl derivatives via methylsulfonyl or p-toluenesulfonyl esters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296754" target="_blank" >RIV/00216208:11310/15:10296754 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/15:00445959
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0022328X15300590" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022328X15300590</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2015.06.032" target="_blank" >10.1016/j.jorganchem.2015.06.032</a>

Result language
angličtina
Original language name
Chemistry of cobalt bis(1,2-dicarbollide) ion; the synthesis of carbon substituted alkylamino derivatives from hydroxyalkyl derivatives via methylsulfonyl or p-toluenesulfonyl esters
Original language description
In this paper we report the synthetic procedures providing the C-substitution of the cobalt bis(dicarbollide) sandwich anion [(1,2-C2B9H11)-3,30-Co] with primary, secondary and tertiary alkylamine groups of different length of the aliphatic spacer attached to the carbon C(1) or C(1) and C(10) cage positions. Reaction pathways leading to these compounds proceed via synthesis of mono [(1-X-O-(CH2)n- 1,2-C2B9H10) (10,20-C2B9H11)-3,30-Co]Me4N (where n 1/4 1e3 and X 1/4 eSO2CH3 or eSO2(-C6H4-4-CH3) esters (2aef) and diesters [(1,10-X-O-(CH2)n-1,2-C2B9H10)2-3,30-Co]Me4N (3a-c) (n 1/4 1 and 2). These compounds are readily accessible in good to excellent yields by reactions of trimethylammonium salts of alkylhydroxy derivatives (1aee) of the parent ion with methylsulfonyl or p-toluenesulfonyl chloride. The esterifications proceeded with lower conversions only for methylene hydroxy derivatives. The series of primary amines of general formulation [(1-1R2RN-(CH2)n-1,2-C2B9H10) (10,20-C2B9H11)-3,3
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA15-05677S" target="_blank" >GA15-05677S: Novel metallacarborane derivatives that exhibit inhibitory properties towards carbonic anhydrase enzyme and potential applicability in cancer therapy</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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