Nanofibers for drug delivery - incorporation and release of model molecules, influence of molecular weight and polymer structure

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10311984" target="_blank" >RIV/00216208:11310/15:10311984 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/15:00447826
Result on the web
<a href="http://dx.doi.org/10.3762/bjnano.6.198" target="_blank" >http://dx.doi.org/10.3762/bjnano.6.198</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjnano.6.198" target="_blank" >10.3762/bjnano.6.198</a>

Result language
angličtina
Original language name
Nanofibers for drug delivery - incorporation and release of model molecules, influence of molecular weight and polymer structure
Original language description
Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using Nanospider (TM) technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile ofincorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences ofthe molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct - the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanof
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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