The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10313493" target="_blank" >RIV/00216208:11310/15:10313493 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007/s00204-014-1360-1#/page-1" target="_blank" >http://link.springer.com/article/10.1007/s00204-014-1360-1#/page-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00204-014-1360-1" target="_blank" >10.1007/s00204-014-1360-1</a>
Alternative languages
Result language
angličtina
Original language name
The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats
Original language description
Exposure to the plant nephrotoxin and carcinogen aristolochic acid (AA) leads to the development of AA nephropathy, Balkan endemic nephropathy (BEN) and upper urothelial carcinoma (UUC) in humans. Beside AA, exposure to ochratoxin A (OTA) was linked to BEN. Although OTA was rejected as a factor for BEN/UUC, there is still no information whether the development of AAinduced BEN/UUC is influenced by OTA exposure. Therefore, we studied the influence of OTA on the genotoxicity of AA (AA-DNA adduct formation) in vivo. AA-DNA adducts were formed in liver and kidney of rats treated with AA or AA combined with OTA, but no OTA-related DNA adducts were detectable in rats treated with OTA alone or OTA combined with AA. Compared to rats treated with AA alone, AA-DNA adduct levels were 5.4- and 1.6-fold higher in liver and kidney, respectively, of rats treated with AA combined with OTA. Although AA and OTA induced NAD(P)H:quinone oxidoreductase (NQO1) activating AA to DNA adducts, their combined tr
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Toxicology
ISSN
0340-5761
e-ISSN
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Volume of the periodical
89
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
18
Pages from-to
2141-2158
UT code for WoS article
000365417800020
EID of the result in the Scopus database
2-s2.0-84947573720