Retroviral proteases and their roles in virion maturation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314895" target="_blank" >RIV/00216208:11310/15:10314895 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00444846
Result on the web
<a href="http://dx.doi.org/10.1016/j.virol.2015.03.021" target="_blank" >http://dx.doi.org/10.1016/j.virol.2015.03.021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.virol.2015.03.021" target="_blank" >10.1016/j.virol.2015.03.021</a>
Alternative languages
Result language
angličtina
Original language name
Retroviral proteases and their roles in virion maturation
Original language description
Proteolytic processing of viral polyproteins is essential for retrovirus infectivity. Retroviral proteases (PR) become activated during or after assembly of the immature, non-infectious virion. They cleave viral polyproteins at specific sites, inducing major structural rearrangements termed maturation. Maturation converts retroviral enzymes into their functional form, transforms the immature shell into a metastable state primed for early replication events, and enhances viral entry competence. Not onlycleavage at all PR recognition sites, but also an ordered sequence of cleavages is crucial. Proteolysis is tightly regulated, but the triggering mechanisms and kinetics and pathway of morphological transitions remain enigmatic. Here, we outline PR structures and substrate specificities focusing on HIV PR as a therapeutic target. We discuss design and clinical success of HIV PR inhibitors, as well as resistance development towards these drugs. Finally, we summarize data elucidating the ro
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virology
ISSN
0042-6822
e-ISSN
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Volume of the periodical
479
Issue of the periodical within the volume
May 2015
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
403-417
UT code for WoS article
000354909500036
EID of the result in the Scopus database
2-s2.0-84937511797