Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10316312" target="_blank" >RIV/00216208:11310/15:10316312 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00444115 RIV/00023001:_____/15:00059349
Result on the web
<a href="http://dx.doi.org/10.1111/apha.12489" target="_blank" >http://dx.doi.org/10.1111/apha.12489</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apha.12489" target="_blank" >10.1111/apha.12489</a>
Alternative languages
Result language
angličtina
Original language name
Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
Original language description
AimIt has been demonstrated that tumour necrosis factor-alpha (TNF-) via its receptor 2 (TNFR2) plays a role in the cardioprotective effects of preconditioning. It is also well known that chronic hypoxia is associated with activation of inflammatory response. With this background, we hypothesized that TNF- signalling may contribute to the improved ischaemic tolerance of chronically hypoxic hearts. MethodsAdult male Wistar rats were kept either at room air (normoxic controls) or at continuous normobarichypoxia (CNH; inspired O-2 fraction 0.1) for 3weeks; subgroups of animals were treated with infliximab (monoclonal antibody against TNF-; 5mgkg(-1), i.p., once a week). Myocardial levels of oxidative stress markers and the expression of selected signalling molecules were analysed. Infarct size (tetrazolium staining) was assessed in open-chest rats subjected to acute coronary artery occlusion/reperfusion. ResultsCNH increased myocardial TNF- level and expression of TNFR2; this response wa
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Physiologica
ISSN
1748-1708
e-ISSN
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Volume of the periodical
214
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
97-108
UT code for WoS article
000353648300010
EID of the result in the Scopus database
2-s2.0-84927615290