Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00043491" target="_blank" >RIV/00216224:14110/10:00043491 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

Original language description

There is a growing evidence that cytokines act as crucial signaling molecules for response of peripheral nerves to injury. We studied levels of tumor necrosis factor alpha (TNF-a) and interleukin 10 (IL-10) proteins using ELISA in the ipsi- and contralateral lumbar and cervical dorsal root ganglia (DRG) from naive rats, rats operated for unilateral chronic constriction injury (CCI) of the sciatic nerve, and sham-operated rats. The ipsilateral hind paws of all operated rats displayed decreased withdrawalthresholds for mechanical allodynia and thermal hyperalgesia, while no significant changes were found in the contralateral hind paws and both forepaws. Bilateral elevation of TNF-a and IL-10 protein was induced in both the lumbar and cervical DRG not only in the homonymous DRG but also in the DRG unassociated with the injured nerve.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GA309%2F07%2F0121" target="_blank" >GA309/07/0121: Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of neuroinflammation

ISSN

1742-2094

e-ISSN

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Volume of the periodical

7/2010

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000274831200001

EID of the result in the Scopus database

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