Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00069542" target="_blank" >RIV/00216224:14740/13:00069542 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00394844 RIV/68081707:_____/13:00440580
Result on the web
<a href="http://www.jneuroinflammation.com/content/10/1/55" target="_blank" >http://www.jneuroinflammation.com/content/10/1/55</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1742-2094-10-55" target="_blank" >10.1186/1742-2094-10-55</a>
Alternative languages
Result language
angličtina
Original language name
Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve
Original language description
Background: Current research implicates interleukin (IL)-6 as a key component of the nervous-system response to injury with various effects. Methods: We used unilateral chronic constriction injury (CCI) of rat sciatic nerve as a model for neuropathic pain. Immunofluorescence, ELISA, western blotting and in situ hybridization were used to investigate bilateral changes in IL-6 protein and mRNA in both lumbar (L4-L5) and cervical (C7-C8) dorsal root ganglia (DRG) following CCI. The operated (CCI) and sham-operated (sham) rats were assessed after 1, 3, 7, and 14 days. Withdrawal thresholds for mechanical hyperalgesia and latencies for thermal hyperalgesia were measured in both ipsilateral and contralateral hind and fore paws.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroinflammation
ISSN
1742-2094
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
22
Pages from-to
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UT code for WoS article
000319195400001
EID of the result in the Scopus database
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