Association of Adenovirus 36 Infection With Obesity-Related Gene Variants in Adolescents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10316440" target="_blank" >RIV/00216208:11310/15:10316440 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/15:43910487 RIV/00023761:_____/15:#0000554

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_S197.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_S197.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of Adenovirus 36 Infection With Obesity-Related Gene Variants in Adolescents

Original language description

Both, common gene variants and human adenovirus 36 (Adv36) are involved in the pathogenesis of obesity. The potential relationship between these two pathogenic factors has not yet been investigated. The aim of our study was to examine the association ofobesity susceptibility loci with Adv36 status. Genotyping of ten gene variants (in/ near TMEM18, SH2B1, KCTD15, PCSK1, BDNF, SEC16B, MC4R, FTO) and analysis of Adv36 antibodies was performed in 1,027 Czech adolescents aged 13.0-17.9 years. Variants of two genes (PCSK1 and BDNF) were associated with Adv36 seropositivity. A higher prevalence of Adv36 antibody positivity was observed in obesity risk allele carriers of PCSK1 rs6232, rs6235 and BDNF rs4923461 vs. noncarriers (X-2=6.59, p=0.010;X-2=7.56, p=0.023 and X-2=6.84, p=0.033, respectively). The increased risk of Adv36 positivity was also found in PCSK1 variants: rs6232 (OR=1.67, 95 % CI 1.11-2.49, p=0.016) and rs6235 (OR=1.34, 95 % CI 1.08-1.67, p=0.010). PCSK1 rs6232 and BDNF rs9259

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT13792" target="_blank" >NT13792: Environmental and behavioral determinants of abdominal obesity and cardiometabolic health risks in Czech adolescents.</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

JULY 2015

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S197"-"S202"

UT code for WoS article

000365011800013

EID of the result in the Scopus database

2-s2.0-84952646411