Metabolic and Hormonal Consequencies of the ,,Obesity Risk" MC4R Variant (rs12970134) in Czech Women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10317384" target="_blank" >RIV/00216208:11310/15:10317384 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/15:#0000553

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Metabolic and Hormonal Consequencies of the ,,Obesity Risk" MC4R Variant (rs12970134) in Czech Women

Original language description

Although the mutations in MC4R gene became known as the most common genetic cause of human obesity, the effect of rs12970134 A/G near MC4R gene on insulin resistance has been described. The aim of this study was to determine the effect of rs12970134 on obesity, hormone levels, and glucose metabolism in a cohort of women varying in glucose tolerance: 850 normoglycemic women, 423 diagnosed with polycystic ovary syndrome ( PCOS), 402 gestational diabetics (GDM), and 250 type 2 diabetic (T2D) women. We didnot confirm the explicit effect of rs12970134 on obesity. However, the influence of the A-allele on body adiposity index was observed in a cohort of women diagnosed with PCOS. In normoglycemic women, the A-allele carriership was associated with lower fasting levels of glucose, insulin, C-peptide, and index of insulin resistance. Furthermore, higher levels of growth hormone, leptin and SHBG, and lower levels of fT3, testosterone, and androstenedione were recorded in normoglycemic A-allele

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT13544" target="_blank" >NT13544: Role of Genetic Variability in the Pathogenesis of Type 2 Diabetes Mellitus and Gestational Diabetes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

Supplement 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

"S187"-"S195"

UT code for WoS article

000365011800012

EID of the result in the Scopus database

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