Endocrine disruptors, obesity, and cytokines - how relevant are they to PCOS?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43920415" target="_blank" >RIV/60461373:22330/20:43920415 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/20:N0000033 RIV/00064165:_____/20:10417454
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/2020/S2_20.htm" target="_blank" >https://www.biomed.cas.cz/physiolres/2020/S2_20.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934521" target="_blank" >10.33549/physiolres.934521</a>
Alternative languages
Result language
angličtina
Original language name
Endocrine disruptors, obesity, and cytokines - how relevant are they to PCOS?
Original language description
As environmental and genetic components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using the Mann-Whitney U test. Spearman correlation coefficients were calculated for the individual parameters relationship. Significantly higher levels of BPA, anti-Mullerain hormone, lutropine, lutropine/folitropine ratio, testosterone, androstenedione, 7 beta-OH-epiandrosterone, and cytokines (IL-6, VEGF, PDGF-bb), were found in normal-weight PCOS women compared to controls. Between normal-weight and obese PCOS women, there were no differences in hormonal, but in metabolic parameters. Obese PCOS women had significantly higher insulin resistance, fatty-liver index, triglycerides, cytokines (IL-2, IL-13, IFN-gamma). In healthy, but not in PCOS, women, there was a positive correlation of BPA with testosterone, SHBG with lutropine, and folitropine, while testosterone negatively correlated with SHBG. In obese women with PCOS, insulin resistance negatively correlated with SHBG and estradiol. No differences were observed in the paraben exposure. Levels of BPA were higher in PCOS women, indicating its role in the etiology. Obesity significantly worsens the symptoms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
Září 2020
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
15
Pages from-to
"S279"-"S293"
UT code for WoS article
000581646000012
EID of the result in the Scopus database
2-s2.0-85094578966