Targeting the Checkpoint to Kill Cancer Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10317646" target="_blank" >RIV/00216208:11310/15:10317646 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/15:00455240

Result on the web

<a href="http://www.mdpi.com/2218-273X/5/3/1912" target="_blank" >http://www.mdpi.com/2218-273X/5/3/1912</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biom5031912" target="_blank" >10.3390/biom5031912</a>

Result language

angličtina

Original language name

Targeting the Checkpoint to Kill Cancer Cells

Original language description

Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress, inhibiting the checkpoint kinases alone could act as a directed anti-cancer therapy. Here, we review the current status of inhibitors targeted towards the checkpoint effectors and discuss mechanisms of their actions in killing of cancer cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA14-34264S" target="_blank" >GA14-34264S: Role of R2TP complex in DNA damage response and cell proliferation</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomolecules [online]

ISSN

2218-273X

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

26

Pages from-to

1912-1937

UT code for WoS article

000362504200034

EID of the result in the Scopus database

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