Cytotoxic Active Constituents of Essential Oils of Curcuma longa and Curcuma zanthorrhiza

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10317738" target="_blank" >RIV/00216208:11310/15:10317738 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cytotoxic Active Constituents of Essential Oils of Curcuma longa and Curcuma zanthorrhiza

Original language description

The polar and apolar fractions of Curcuma longa and C. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the HeLa cell line. Actinomycin D and curcumin were used as reference samples, both known for their cytotoxic properties. Amongst all fractions tested, the xanthorrizol fraction (CC50: 26.1 +/- 1.9 mu M) showed the strongest cytotoxic properties similar to those of curcumin (CC50: 8.1 +/- 1.7 mu M). Further studies also revealed that thecytotoxic effects of the extracts and pure compounds are caused by apoptosis induction identified by the cleaved form of PARP protein

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural product communications

ISSN

1934-578X

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

139-141

UT code for WoS article

000348825700030

EID of the result in the Scopus database

2-s2.0-84937559902