Plasmonic Nanodiamonds: Targeted Core-Shell Type Nanoparticles for Cancer Cell Thermoablation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10319197" target="_blank" >RIV/00216208:11310/15:10319197 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/15:00443671 RIV/00216208:11110/15:10319197

Result on the web

<a href="http://dx.doi.org/10.1002/adhm.201400421" target="_blank" >http://dx.doi.org/10.1002/adhm.201400421</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adhm.201400421" target="_blank" >10.1002/adhm.201400421</a>

Result language

angličtina

Original language name

Plasmonic Nanodiamonds: Targeted Core-Shell Type Nanoparticles for Cancer Cell Thermoablation

Original language description

Targeted biocompatible nanostructures with controlled plasmonic and morphological parameters are promising materials for cancer treatment based on selective thermal ablation of cells. Here, core-shell plasmonic nanodiamonds consisting of a silica-encapsulated diamond nanocrystal coated in a gold shell are designed and synthesized. The architecture of particles is analyzed and confirmed in detail using electron tomography. The particles are biocompatibilized using a PEG polymer terminated with bioorthogonally reactive alkyne groups. Azide-modified transferrin is attached to these particles, and their high colloidal stability and successful targeting to cancer cells overexpressing the transferrin receptor are demonstrated. The particles are nontoxic to the cells and they are readily internalized upon binding to the transferrin receptor. The high plasmonic cross section of the particles in the near-infrared region is utilized to quantitatively ablate the cancer cells with a short, one-min

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced healthcare materials

ISSN

2192-2640

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

460-468

UT code for WoS article

000349961600014

EID of the result in the Scopus database

2-s2.0-84923032732